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Updated: Jun 27, 2026

Diagonal Method to Measure Synergy Among Any Number of Drugs
Published on: June 21, 2018
[Quantitative approach for calculation of pharmacodynamic interactions and simulation of combined response]
Jun-chao Chen1, You-jun Pan, Xing-shan Li
1Center for Drug Clinical Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Objective:
An approach is set up to calculate pharmacodynamic interaction and simulate the combined response.
Method:
An orthogonal design with 1-level = high dose and 2-level = low dose was adopted. An example of the compound with four components was applied to evaluate this quantitative approach. The bias was evaluated by the both scatter plots.
Result:
This approach can calculate the value of each component with different dose by its contribution to combined response, and the value is related to the importance of a compound. Drug interactions were evaluated among the combinations in each group. The prediction model performed well and simulated the combined response in the different of components in combination.
Conclusion:
The approach can be used in the similar research, and it also provides predictions of component combinations from the other studies by simulation.
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