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[Effect of verapamil on pharmacokinetics of puerarin in rats]
1Department of Traditional Chinese Materia Medica, Guangdong Pharmaceutical University, Guangzhou 510006, China. cuishengmiao@yahoo.com
Objective:
To investigate the effect of verapamil on the pharmacokinetics of puerarin in rats.
Method:
Puerarin with or without verapamil was administered intravenously or orally to rats. The concentration of puerarin in serum was determined by HPLC.
Result:
No significant difference was found between the control and 0.5 microg x g(-1) verapamil combined groups for intravenous administration, and there was significant difference between the control and 2. 5 microg x g(-1) verapamil combined groups (P < 0.05). When puerarin was administered orally with verapamil, significant difference was found between the control and combined groups (P < 0.05).
Conclusion:
Verapamil inhibited puerarin metabolism when puerarin was coadministered with verapamil, so it is necessary to change the therapeutic dose of puerarin.
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