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Updated: Jun 27, 2026
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Published on: August 2, 2024
A randomised trial comparing the H Pipelle with the standard Pipelle for endometrial sampling at 'no-touch'
S Madari1, N Al-Shabibi, P Papalampros
1University Department of Obstetrics and Gynaecology, Royal Free Hospital, Pond Street, Hampstead, London NW3 2QG, UK.
Objectives:
To evaluate the effectiveness and tolerance of H Pipelle compared with the standard Pipelle as an endometrial biopsy device at outpatient 'no-touch' hysteroscopy.
Design:
A prospective randomised trial carried out in an outpatient diagnostic hysteroscopy clinic.
Setting:
A large undergraduate teaching hospital.
Population:
Sixty women investigated for abnormal menstruation in an outpatient diagnostic hysteroscopy clinic.
Methods:
Prospective randomised trial comparing the H Pipelle with the standard Pipelle de Cornier.
Main Outcome Measures:
Adequacy of the biopsy specimens and women's experience.
Results:
Ninety-three percent (H Pipelle) and 87% (Pipelle) of the biopsy specimens were judged to be adequate for histological diagnosis (P > 0.05). However, obtaining endometrial sampling with the H Pipelle was significantly quicker (median times: 39 seconds [H Pipelle] and 102 seconds [Pipelle], P < 0.0001) and less painful (median visual analogue scale score: 1 [H Pipelle] and 5 [Pipelle], P = 0.011).
Conclusions:
The H Pipelle not only makes it possible to perform hysteroscopy and endometrial biopsy with minimal instrumentation but is also associated with a shorter biopsy time and less discomfort than the standard Pipelle without any loss of biopsy adequacy.
