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Related Experiment Video

Updated: Jun 27, 2026

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Isolation of Leukocytes from Human Breast Milk for Use in an Antibody-dependent Cellular Phagocytosis Assay of HIV Targets

Published on: September 6, 2019

Breast-feeding and HIV transmission.

A Coutsoudis¹

¹Department of Paediatrics and Child Health, University of Natal, Private Bag 7, Congella 4013, South Africa.

Nutrition Research Reviews

|December 18, 2008

Summary

Reducing HIV transmission risk during breastfeeding involves balancing infant health with maternal infection stage and feeding duration. Exclusive breastfeeding with early cessation may be a viable option.

Area of Science:

Public Health
Infectious Diseases
Pediatrics

Background:

Breastfeeding can transmit Human Immunodeficiency Virus (HIV) from mother to infant.
Transmission risk is influenced by maternal infection stage, breastfeeding duration, feeding type, and breast health.
Previous research indicates a 14% HIV transmission risk with over two years of breastfeeding.

Purpose of the Study:

To review strategies for minimizing HIV transmission risk through breastfeeding.
To evaluate the risks and benefits of breastfeeding cessation versus formula feeding in resource-poor settings.
To explore the potential of exclusive breastfeeding with early cessation as a risk reduction method.

Main Methods:

Review of existing studies and meta-analyses on HIV transmission via breastfeeding.

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Published on: September 22, 2023

Analysis of factors influencing postnatal HIV transmission.

Evaluation of infant health outcomes associated with different feeding practices.

Main Results:

Shorter breastfeeding durations may reduce HIV transmission risk.
Exclusive breastfeeding may not increase HIV transmission risk at six months compared to mixed feeding.
Large-scale replacement feeding programs can be detrimental in resource-poor settings due to low education and poor access to services.

Conclusions:

Strategies exist to reduce HIV transmission risk during breastfeeding.
Policy decisions regarding infant feeding must consider the risks of malnutrition and mortality associated with formula feeding in resource-limited areas.
Exclusive breastfeeding with early cessation presents a potential option for some mothers to mitigate HIV transmission risks.