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Updated: Jun 27, 2026

Three-dimensional Rendering and Analysis of Immunolabeled, Clarified Human Placental Villous Vascular Networks
Published on: March 29, 2018
[Comparison between transabdominal and transcervical chorionic villus sampling in clinical application for prenatal
Yan-Min Luo1, Qun Fang, Yong-Zhong Yang
1Fetal Medicine Center, Department of Obstetrics and Gynecology, First Affiliated Hospital of Sun Yat-Sen University, Guangzhou 510080, China.
Objective:
To compare transabdominal and transcervical chorionic villus sampling (TC-CVS) in application for prenatal diagnosis, and to summarize the experience of transabdominal chorionic villus sampling (TA-CVS).
Methods:
One hundred and nine TA-CVS between April 2005 and November 2007 and 69 TC-CVS between August 1999 and March 2005 were retrospectively analyzed.
Results:
(1) The mean gestational age was (12.4 +/- 1.9) weeks at TA-CVS and (8.8 +/- 1.2) weeks at TC-CVS (P < 0.01). (2) Compared with TC-CVS, punctures were fewer (1.4 +/- 0.5) and (1.1 +/- 0.4) and specimen amount was more (9 +/- 5) mg and (17 +/- 5) mg in TA-CVS, and the success rate of one puncture (62.3% vs 87.2%) was higher in TA-CVS. (3) Among the cases followed up, the incidence of vaginal bleeding (TA-CVS: 2 cases, 2.0%; TC-CVS: 2 cases, 6.1%) and spontaneous abortion (TA-CVS: 4 cases, 4.0%; TC-CVS: 1 cases, 3.0%) were not significantly different between the two groups (P > 0.05).
Conclusion:
TA-CVS appears to be a good method for early prenatal diagnosis with a wide range of indications, high success rate and sufficient specimen.
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