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[Lamivudine treatment of a HBs antigen positive man with reactive arthritis]

Christian Borup1, Anders Siboni

  • 1Medicinsk Afdeling, Sygehus Sønderjylland Haderslev, DK-6100 Haderslev.

Ugeskrift for Laeger
|December 18, 2008
PubMed

A 46-year-old man who was HBs antigen positive since childhood had painful talocrural arthritis that was considered re-active to HBs antigen. Lamivudine treatment was started and HBV-DNA disappeared from the blood, and the joint swellings disappeared. HBe antibody disappeared after eight months. After one year and nine months lamivudine was discontinued, resulting in a flare of the hepatitis after 56 days: HBV-DNA rose to 40 million copies per ml and HBe antigen became positive. Lamivudine was reinstituted, resulting in normalization of ALAT and lowering of HBV-DNA under detection level.

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