Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Stem Cell Niche

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...

Multipotency of Hematopoietic Stem Cells

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Multipotency and Niche of Bulge Stem Cell

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...

Regulation of Hematopoietic Stem Cells

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Glycolysis is intrinsically required in the follicle stem cell lineage but not in female germline stem cells or their early progeny in Drosophila melanogaster.

Genetics·2026

Same author

Dopamine production in the central nervous system is important for follicle survival and interacts with genetic background and a high sugar diet during Drosophila oogenesis.

Genetics·2025

Same author

Brain dopamine imbalance causes follicle death and underlies negative effect of high sugar diet during <i>Drosophila</i> oogenesis.

bioRxiv : the preprint server for biology·2025

Same author

A high-sugar diet, but not obesity, reduces female fertility in Drosophila melanogaster.

Development (Cambridge, England)·2023

Same author

Chronic exposure to warm temperature causes low sperm abundance and quality in Drosophila melanogaster.

Scientific reports·2023

Same author

Warm and cold temperatures have distinct germline stem cell lineage effects during Drosophila oogenesis.

Development (Cambridge, England)·2022

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

Stem cells, their niches and the systemic environment: an aging network.

Daniela Drummond-Barbosa¹

¹Department of Cell and Developmental Biology, Vanderbilt University Medical Center, Nashville, Tennessee 37232, USA. daniela.drummond-barbosa@vanderbilt.edu

|December 18, 2008

Summary

This summary is machine-generated.

Stem cell behavior is influenced by their local environment and broader physiological signals. This review explores stem cell communication networks and their link to the aging process.

More Related Videos

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

Stromal Cell Isolation From Hematopoietic Organs

Stromal Cell Isolation From Hematopoietic Organs

Published on: January 26, 2024

Related Experiment Videos

Last Updated: Jun 27, 2026

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Single Myofiber Culture Assay for the Assessment of Adult Muscle Stem Cell Functionality Ex Vivo

Published on: February 15, 2021

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Cryo-section Dissection of the Adult Subependymal Zone for Accurate and Deep Quantitative Proteome Analysis

Published on: October 7, 2021

Stromal Cell Isolation From Hematopoietic Organs

Stromal Cell Isolation From Hematopoietic Organs

Published on: January 26, 2024

Area of Science:

Stem cell biology
Tissue engineering
Aging research

Background:

Stem cells possess remarkable properties crucial for therapeutic applications.
Understanding stem cell regulation is key to harnessing their potential.
While local niche influences are studied, systemic environmental interactions remain less understood.

Purpose of the Study:

To review the multidirectional interactions among stem cells, niches, tissues, and the systemic environment.
To explore how these communication networks influence stem cell behavior.
To investigate the relationship between these interactions and the aging process.

Main Methods:

Literature review of current research on stem cell interactions.
Analysis of communication pathways between stem cells and their environments.
Exploration of theoretical models linking environmental factors to stem cell aging.

Main Results:

Stem cells are intricately connected to their local niches, tissues, and systemic environments.
These complex interactions dynamically regulate stem cell maintenance and activity.
Alterations in these communication networks are hypothesized to contribute to aging.

Conclusions:

Stem cell function is governed by a complex interplay of local and systemic factors.
Further research into these interactions is essential for understanding aging and developing stem cell therapies.
Investigating the systemic environment's role offers new avenues for therapeutic intervention.