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Duration of etidronate effect demonstrated by serial bone scintigraphy.
E D Sandler1, M T Parisi, R S Hattner
1Department of Radiology, UCSF, California.
Summary
Etidronate disodium (EHDP) can interfere with bone scans. A single dose of EHDP for hypercalcemia resolved interference after 15 days, suggesting a 2-week waiting period before bone scintigraphy.
Area of Science:
- Nuclear Medicine
- Radiopharmacology
Background:
- Etidronate disodium (EHDP) interference with 99mTc-methylene diphosphonate (MDP) biodistribution is reported.
- Increasing EHDP use for Paget's disease, hypercalcemia, and osteoporosis may lead to more bone scan artifacts.
Purpose of the Study:
- To determine the temporal duration of EHDP-induced artifacts on bone scans.
- To establish optimal timing for bone scintigraphy after EHDP administration.
Main Methods:
- Serial bone scintigraphy was performed on a patient receiving a single intravenous dose of EHDP for hypercalcemia.
- Biodistribution of 99mTc-MDP was assessed over time.
Main Results:
- Normal biodistribution of 99mTc-MDP was observed 15 days post-EHDP administration.
- The findings suggest EHDP interference resolves within 2 weeks.
Conclusions:
- A single intravenous dose of EHDP for hypercalcemia does not appear to interfere with bone scans after 15 days.
- A 2-week interval is likely sufficient before performing bone scintigraphy following a single EHDP dose.