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[Hepatitis C virus (HCV) infection in childhood]

I Nagata1, K Shiraki

  • 1Department of Pediatrics, Tottori University, School of Medicine, Yonago.

Rinsho Byori. the Japanese Journal of Clinical Pathology
|June 1, 1991
PubMed

Insights

Hepatitis C virus (HCV) infection is prevalent in children, especially after transfusions. Mother-to-infant transmission is also a significant concern, leading to liver dysfunction in infants.

Area of Science:

  • Pediatric Infectious Diseases
  • Hepatology
  • Virology

Background:

  • Hepatitis C virus (HCV) infection poses a significant health risk in pediatric populations.
  • Understanding the transmission routes and prevalence of HCV in children is crucial for effective prevention and treatment strategies.

Purpose of the Study:

  • To determine the prevalence of HCV infection in children with different forms of non-A, non-B hepatitis.
  • To investigate the potential for mother-to-infant transmission of HCV.

Main Methods:

  • HCV antibody testing (Ortho Diagnostic Systems, USA) was performed on pediatric patients with post-transfusion hepatitis, acute hepatitis, and chronic hepatitis.
  • Infants born to HCV-positive mothers were assessed for liver dysfunction (GPT values) and HCV antibodies to evaluate mother-to-infant transmission.

Main Results:

  • Anti-HCV positivity was highest in children with post-transfusion non-A, non-B hepatitis (72.7%).
  • Prevalence was lower in children with acute (25.0%) and chronic (20.0%) non-A, non-B hepatitis.
  • HCV antibody positivity in infants born to infected mothers was 7.5%, with evidence suggesting mother-to-infant transmission and associated liver dysfunction.

Conclusions:

  • HCV infection is a notable concern in children, particularly following blood transfusions.
  • The study provides evidence supporting mother-to-infant transmission of HCV, contributing to infant liver dysfunction.

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