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Published on: October 20, 2011
Slow-release fluoride devices: a literature review
Juliano Pelim Pessan1, Nahla Saleh Al-Ibrahim, Marília Afonso Rabelo Buzalaf
1Department of Paediatric Dentistry and Public Health, Araçatuba Dental School, São Paulo State University, Brazil.
Slow-release fluoride devices offer promising caries prevention for high-risk individuals by maintaining optimal intra-oral fluoride levels. Further clinical trials are needed to improve device retention and validate their use.
Area of Science:
- Dental Research
- Caries Prevention
- Fluoride Therapy
Background:
- Dental caries prevalence has decreased but become polarized, with a few individuals experiencing most disease.
- High-risk patients present challenges in compliance and attendance for conventional dental care.
- Slow-release fluoride devices aim to address these challenges by providing continuous fluoride delivery.
Purpose of the Study:
- To review the effectiveness of slow-release fluoride devices in caries prevention.
- To discuss the two main types of slow-release fluoride devices: copolymer membrane and glass bead.
- To highlight the potential of these devices for high-caries-risk populations.
Main Methods:
- Review of existing studies on slow-release fluoride devices.
- Analysis of data on intra-oral fluoride concentrations and caries experience.
- Evaluation of animal and human studies on device efficacy and protection of occlusal surfaces.
Main Results:
- Slow-release fluoride devices effectively increase intra-oral fluoride levels, reducing enamel solubility and providing caries protection.
- These devices demonstrate efficacy in protecting occlusal surfaces, which are often not covered by conventional fluoride treatments.
- Device retention rates remain a significant challenge requiring further improvement.
Conclusions:
- Slow-release fluoride devices show promising results for caries prevention in high-risk groups.
- Continuous low-level intra-oral fluoride delivery has substantial potential for managing dental caries.
- Further randomized clinical trials are necessary to confirm the clinical utility and optimize the application of these devices.
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Modified-Release Drug Delivery Systems: Drug Release Characteristics
Oral Drug Delivery Systems: Delayed-Release Systems
Modified-Release Drug Delivery Systems: Rate-Programmed II

