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Updated: Jun 27, 2026
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NO and sGC-stimulating NO donors.
1Free Radical Research Facility, Department of Diabetes, UHI Millennium Institute, Inverness, Scotland, IV2 3BL, UK. Ian.megson@uhi.ac.uk
Nitric oxide (NO) is a vital signaling molecule in mammals, primarily acting through soluble guanylyl cyclase (sGC). This review covers NO
Area of Science:
- Biochemistry
- Physiology
- Pharmacology
Background:
- Nitric oxide (NO) is an essential endogenous signaling molecule.
- Many NO functions involve activating soluble guanylyl cyclase (sGC).
Purpose of the Study:
- To summarize NO functions in mammalian biology.
- To discuss the chemistry of NO signaling.
- To review NO donor drugs for research and therapy.
Main Methods:
- Literature review of NO functions.
- Analysis of NO chemistry.
- Evaluation of NO donor drug utility and therapeutic potential.
Main Results:
- NO plays diverse roles in mammalian systems.
- NO's chemical properties are key to its signaling.
- Appropriate NO donor selection is critical for experimental and clinical success.
Conclusions:
- Understanding NO's functions and chemistry is crucial.
- Careful selection of NO donors enhances experimental and therapeutic outcomes.
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