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Related Experiment Video

Updated: Jun 27, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

Published on: May 30, 2025

Erectile dysfunction and lower urinary tract.

Peter Sandner¹, Dieter Neuser, Erwin Bischoff

¹Global Drug Discovery-Research Centre Wuppertal, Bayer Schering Pharma, Aprather Weg 18a, Wuppertal, 42069, Germany. peter.sandner@bayerhealthcare.com

Handbook of Experimental Pharmacology

|December 18, 2008

Summary

This summary is machine-generated.

The NO/cGMP pathway regulates many bodily functions. Targeting this pathway with drugs that increase cyclic GMP (cGMP) offers therapeutic potential for erectile dysfunction and other urological conditions.

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Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

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Published on: August 14, 2019

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Last Updated: Jun 27, 2026

Treatment Model for Young Patients with Psychogenic Erectile Dysfunction and Resultant Infertility

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Published on: May 30, 2025

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Ultrasonography of the Adult Male Urinary Tract for Urinary Functional Testing

Published on: August 14, 2019

Area of Science:

Pharmacology
Urology
Physiology

Background:

The nitric oxide/cyclic guanosine monophosphate (NO/cGMP) signaling cascade is a crucial regulator in mammalian tissues.
cGMP acts as a key second messenger, and pharmacological interventions targeting this pathway are clinically successful.

Purpose of the Study:

To summarize the therapeutic effects of cGMP elevation in urological disorders.
To review evidence for treating erectile dysfunction (ED), benign prostatic hyperplasia (BPH), lower urinary tract symptoms (LUTS), and overactive bladder (OAB).

Main Methods:

Literature review of pre-clinical and clinical studies.
Analysis of the role of NO/cGMP signaling in male and female lower urinary tract function.

Main Results:

cGMP elevation is effective for treating ED in both males and females.
Evidence supports cGMP-targeting drugs for BPH, LUTS, OAB, and potentially premature ejaculation, Peyronie's disease, and stone disease.

Conclusions:

The NO/cGMP pathway holds significant therapeutic promise for a range of urological conditions beyond ED.
Further research into cGMP-modulating drugs could lead to novel treatments for various lower urinary tract disorders.