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Candidiasis

Candidiasis

Candidiasis is a fungal infection caused by opportunistic species of Candida. It can affect various anatomical sites, including the skin, oral cavity, nails, and genitourinary tract. Among its forms, vaginal candidiasis is the most common type of mucosal infection. It typically results from the overgrowth of Candida albicans in the vaginal mucosa. Under normal conditions, C. albicans exists as a commensal organism within the vaginal microbiota, regulated by the dominance of lactobacilli, which...

Adherens Junctions

Adherens Junctions

Strong contact points between adjacent cells anchor them to each other, forming tissues. Such anchoring junctions are of two types – adherens junctions and desmosomes. Adherens junctions are abundant in tissues such as epithelium and endothelium, forming a continuous zone of adhesion called the adhesion belt. In other tissues, such as heart muscle, they appear as clusters, linking the cells to produce coordinated heart muscle contraction.
Adherens Junctions are Dynamic
The endothelial cells...

Selectins

Selectins

Cell adhesion is an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like Cell Adhesion Molecules

Immunoglobulin-like cell adhesion molecules or Ig-CAMs are a versatile group of cell surface glycoproteins belonging to the immunoglobulin protein superfamily. Ig-CAMs possess the characteristic immunoglobulin protein domains and other domains such as the fibronectin type III domain. The Ig domains are glycosylated to varying degrees in different Ig-CAMs.
Ig-CAMs exhibit either homophilic binding (to other Ig-CAMs) or heterophilic binding (to other ligands such as integrins). While most Ig-CAMs...

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Related Experiment Video

Updated: Jun 27, 2026

Live-cell Video Microscopy of Fungal Pathogen Phagocytosis

Live-cell Video Microscopy of Fungal Pathogen Phagocytosis

Published on: January 9, 2013

Endothelial cell stimulation by Candida albicans.

Quynh T Phan¹, Scott G Filler

¹Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California, USA.

Methods in Molecular Biology (Clifton, N.J.)

|December 18, 2008

Summary

This study investigated how Candida albicans affects endothelial cells, finding it increases E-selectin and tumor necrosis factor alpha production. This research is crucial for understanding disseminated fungal infections in hospitalized patients.

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A Catheter-Related Candida albicans Infection Model in Mouse

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Last Updated: Jun 27, 2026

Live-cell Video Microscopy of Fungal Pathogen Phagocytosis

Live-cell Video Microscopy of Fungal Pathogen Phagocytosis

Published on: January 9, 2013

A Catheter-Related Candida albicans Infection Model in Mouse

A Catheter-Related Candida albicans Infection Model in Mouse

Published on: March 22, 2024

Area of Science:

Mycology
Immunology
Cell Biology

Background:

Candida albicans is an opportunistic fungal pathogen causing disseminated infections.
Endothelial cells are primary host cells interacting with C. albicans during bloodstream infections.
Endothelial cells modulate host immune responses through adhesion molecules and cytokines.

Purpose of the Study:

To investigate the in vitro response of endothelial cells to Candida albicans.
To quantify the impact of C. albicans on endothelial cell production of key inflammatory mediators.

Main Methods:

Utilized real-time PCR to measure gene expression.
Employed enzyme immunoassays to assess protein production.
Studied endothelial cell responses to C. albicans in vitro.

Main Results:

Candida albicans significantly increased endothelial cell production of E-selectin.
Tumor necrosis factor alpha production by endothelial cells was also elevated following C. albicans exposure.
Demonstrated a measurable in vitro endothelial cell response to the fungal pathogen.

Conclusions:

Candida albicans modulates endothelial cell behavior, promoting inflammation.
Findings provide insights into the early host-pathogen interactions during disseminated candidiasis.
This research highlights the role of endothelial cells in the host defense against fungal infections.