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Related Concept Videos

Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
Myocarditis III: Medical Management01:14

Myocarditis III: Medical Management

Myocarditis: Comprehensive Medical ManagementMyocarditis, the heart muscle inflammation, requires a comprehensive medical management strategy that addresses the underlying cause, provides supportive care, manages symptoms, and reduces cardiac workload.Infections and Autoimmune CausesAdminister appropriate antimicrobial therapy when an infectious agent causes myocarditis. For instance, penicillin treats infections caused by Group A Streptococcus. In cases where autoimmune processes are...
Rocky Mountain Spotted Fever01:26

Rocky Mountain Spotted Fever

Rocky Mountain Spotted Fever (RMSF) is a severe tick-borne illness caused by Rickettsia rickettsii, a Gram-negative, coccobacillary bacterium. This pathogen is an obligate intracellular parasite, requiring a host cell for replication. Transmission occurs through the bite of an infected tick. In the United States, the most important vectors are Dermacentor variabilis (American dog tick) and Dermacentor andersoni (Rocky Mountain wood tick), though other tick species may also serve as vectors.

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Related Experiment Video

Updated: Jun 27, 2026

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Dermatomyositis with hemorrhagic myositis.

Masashi Yamagishi1, Shunji Tajima, Aki Suetake

  • 1Division of Respiratory Medicine, Niigata University Graduate School of Medical and Dental Sciences, Niigata 951-8510, Japan.

Rheumatology International
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

This case report details a rare instance of dermatomyositis complicated by hemorrhagic myositis and small aneurysms. The patient presented with abdominal pain, leading to the identification of bleeding foci and subsequent arterial embolization.

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Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy
10:55

Detection of Anti-MDA5 Autoantibodies Using HeLa Cells and Immunocytochemistry with Light Microscopy

Published on: October 31, 2025

Area of Science:

  • Rheumatology
  • Vascular Medicine
  • Pathology

Background:

  • Dermatomyositis is an idiopathic inflammatory myopathy characterized by muscle inflammation and characteristic skin rashes.
  • Acute interstitial pneumonia is a severe lung complication that can occur in patients with dermatomyositis.
  • Hemorrhagic complications in dermatomyositis are uncommon, with limited literature on associated vascular abnormalities.

Observation:

  • A 64-year-old female with dermatomyositis and acute interstitial pneumonia presented with acute abdominal pain.
  • Abdominal CT revealed retroperitoneal and rectus-sheath hematomas.
  • Angiography identified multiple small aneurysms on the left iliolumbar artery with active bleeding.

Findings:

  • Arterial embolization successfully achieved hemostasis for the active bleeding.
  • The patient ultimately succumbed to thrombotic thrombocytopenic purpura and multiple organ failure.
  • Systemic vasculitides and infectious causes of microaneurysms were excluded.

Implications:

  • This case highlights a potential, previously unreported association between dermatomyositis and hemorrhagic myositis secondary to small arterial aneurysms.
  • It underscores the importance of considering rare vascular complications in patients with dermatomyositis presenting with unusual bleeding.
  • Further research is warranted to elucidate the pathogenesis and clinical significance of these aneurysms in the context of dermatomyositis.