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Related Concept Videos

Brain Abscess l: Introduction01:26

Brain Abscess l: Introduction

A brain abscess is a focal, intracerebral infection characterized by a localized collection of pus within the brain parenchyma, resulting from microbial invasion and the body’s inflammatory response. It progresses through stages: early and late cerebritis, followed by early and late capsule formation, reflecting tissue destruction, immune response, and eventual encapsulation.Etiology and PathogenesisCausative organisms vary with source and host factors, often involving polymicrobial infections,...
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Understanding the physiological differences in the pediatric population is crucial for effective pharmacotherapy. Neonates, infants, and children exhibit significant variations in gastric pH, gastric emptying time, intestinal transit time, and biliary function. These variations profoundly affect oral drug absorption, necessitating a nuanced approach to pediatric dosing.Neonates present with a unique physiological profile, having a gastric pH greater than 4 and faster and more irregular gastric...

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Related Experiment Video

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Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates
06:10

Extrahepatic Bile Duct and Gall Bladder Dissection in Nine-Day-Old Mouse Neonates

Published on: August 23, 2022

Liver abscess in neonates.

E Simeunovic1, M Arnold, D Sidler

  • 1Division of Paediatric Surgery, Faculty of Health Sciences, University of Stellenbosch, P.O. Box 19063, Tygerberg, 7505, South Africa.

Pediatric Surgery International
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

Neonatal liver abscesses are rare but serious infections. Misplaced umbilical lines and hypertonic glucose infusions are significant risk factors, often requiring drainage beyond antibiotics.

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Area of Science:

  • Neonatology
  • Pediatric Infectious Diseases
  • Medical Imaging

Background:

  • Neonatal liver abscesses are uncommon infections.
  • Typically arise from ascending umbilical/portal vein infections, hematogenous spread, or contiguous spread.
  • Can present insidiously with sepsis, posing diagnostic challenges.

Purpose of the Study:

  • To review clinical and radiological findings of neonatal hepatic abscesses.
  • To identify associated risk factors and predisposing conditions.
  • To emphasize diagnostic and management strategies.

Main Methods:

  • Retrospective chart review of six neonates diagnosed with hepatic abscesses (2000-2006).
  • Involved clinical assessment, radiological imaging (X-ray, Ultrasound), and risk factor evaluation.
  • Analysis of causative organisms and treatment outcomes.

Main Results:

  • Most patients were preterm (30-34 weeks gestation); one was post-mature.
  • Common signs included elevated C-reactive protein (CRP) and sepsis symptoms.
  • Associated factors included misplaced umbilical lines (2/5 right-sided abscesses) and hypertonic glucose infusions (2).
  • Klebsiella, Staphylococcus (including MRSA), Gonococcus, and Enterobacter were identified pathogens.
  • Ultrasound was reliable for diagnosis; 50% required interventional drainage.

Conclusions:

  • Neonatal hepatic abscesses are rare but crucial in the differential diagnosis for neonates with persistent sepsis.
  • A strong association exists with misplaced central (umbilical) catheters.
  • Interventional drainage is necessary for abscesses unresponsive to antibiotic therapy.