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Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
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Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
Oral Drug Delivery Systems: Delayed-Release Systems01:11

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Delayed-release drug delivery systems are specialized pharmaceutical formulations designed to postpone the release of active compounds until the drug reaches a specific region of the gastrointestinal (GI) tract, typically the intestine. These systems are essential for drugs that may cause gastric irritation, are unstable in acidic environments, or need to exert therapeutic effects locally in the intestinal or colonic regions.The core feature of delayed-release systems is the use of enteric...
Oral Drug Delivery Systems: Continuous-Release Systems01:26

Oral Drug Delivery Systems: Continuous-Release Systems

Continuous-release drug delivery systems offer a strategic approach to maintaining therapeutic drug levels over extended periods following oral administration. By modulating the release rate of active pharmaceutical ingredients, these systems minimize fluctuations in plasma concentrations, which enhances clinical efficacy and reduces the need for frequent dosing. Such characteristics make them particularly advantageous in managing chronic diseases where patient adherence and stable drug...
Modified-Release Drug Delivery Systems: Classification01:23

Modified-Release Drug Delivery Systems: Classification

Modified-release drug delivery systems improve drug efficacy and minimize side effects by controlling the rate and location of drug release. These systems fall into three categories: rate-programmed, stimuli-activated, and site-targeted.Rate-programmed systems release drugs at a predetermined rate, maintaining consistent therapeutic levels and reducing fluctuations that could lead to toxicity or subtherapeutic effects. These systems use polymeric matrices, reservoir-based designs, or osmotic...
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Stimuli-activated drug delivery systems are designed to release drugs in response to specific physical, chemical, or biological stimuli. These systems often utilize hydrogels—three-dimensional, hydrophilic polymer networks capable of swelling in aqueous environments and retaining significant fluid volumes. Upon exposure to particular stimuli, these hydrogels undergo structural transitions that allow the embedded drug to be released. Due to this adaptive behavior, such systems are also called...

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Development and Characterization of Fusidic Acid-Loaded Alginate-Aloe vera Based Hydrogel Film
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Release mechanisms behind polysaccharides-based famotidine controlled release matrix tablets.

Enas M Elmowafy1, Gehanne A S Awad, Samar Mansour

  • 1Department of Pharmaceutics, Faculty of Pharmacy, Ain Shams University, Monazamet El Wehda El Afrikia St., El Abbassia, Cairo, Egypt.

AAPS Pharmscitech
|December 18, 2008
PubMed
Summary

This study developed floating matrix tablets using polysaccharides for sustained famotidine release. Blending polymers altered drug release, showing potential for controlled drug delivery systems.

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Published on: February 13, 2016

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Polysaccharides offer gelling properties and safety for drug formulation.
  • Floating drug delivery systems enhance drug absorption by prolonging gastric residence time.

Purpose of the Study:

  • To formulate single-unit floating matrix tablets of famotidine for sustained release.
  • To investigate the effect of various polysaccharides and cellulose ethers on drug release characteristics.
  • To achieve continuous slow release of famotidine above its absorption site.

Main Methods:

  • Direct compression technique used for tablet formulation.
  • Incorporation of low-density polypropylene foam powder for floating capability.
  • Evaluation of tablet properties including floating behavior, matrix integrity, swelling, and in vitro drug release.
  • Analysis of drug release kinetics and molecular interactions using DSC and FTIR.

Main Results:

  • Successful formulation of floating matrix tablets with controlled drug release.
  • Blending of polysaccharides and cellulose ethers modulated famotidine release profiles.
  • Differential scanning calorimetry and FTIR studies indicated molecular interactions within the polymer blends.
  • Retardation in drug release and alteration in release mechanisms were observed due to polymer blending.

Conclusions:

  • Floating matrix tablets formulated with polysaccharides are effective for sustained famotidine delivery.
  • Polymer blending in the matrix system influences drug release kinetics and mechanisms.
  • This approach offers a promising strategy for developing advanced oral drug delivery systems.