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Related Experiment Video

Updated: Jun 27, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

Triple-negative/basal-like breast cancer: review.

Emad A Rakha1, Ian O Ellis

  • 1Department of Histopathology, Nottingham City Hospital NHS Trust, Nottingham University, Nottingham, UK.

Pathology
|December 18, 2008
PubMed
Summary

Triple-negative (TN) breast cancer is aggressive and lacks targeted therapies. This review clarifies the distinctions between TN and basal-like tumors, crucial for identifying new treatments.

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Area of Science:

  • Oncology
  • Molecular Biology
  • Pathology

Background:

  • Breast cancer is a heterogeneous disease with varying treatment responses.
  • Triple-negative (TN) breast cancer exhibits aggressive behavior and limited targeted therapy options.
  • Basal-like tumors, a majority of TN cancers, are molecularly distinct from hormone receptor-positive and HER2-positive tumors.

Purpose of the Study:

  • To differentiate between triple-negative (TN) and basal-like breast cancers.
  • To explore the pathological and clinical features of basal-like cancers.
  • To identify criteria for routine practice identification of these aggressive tumor subtypes.

Main Methods:

  • Review of global gene expression profiling studies.
  • Analysis of molecular and histopathological features.

Related Experiment Videos

Last Updated: Jun 27, 2026

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model
09:29

Studying Triple Negative Breast Cancer Using Orthotopic Breast Cancer Model

Published on: March 20, 2020

  • Comparison of triple-negative and basal-like tumor characteristics.

    • Main Results:

    • Gene expression profiling identified distinct molecular classes of breast cancer.
    • Basal-like tumors share features with TN tumors but are not identical.
    • Understanding these differences is key to developing targeted therapies.

    Conclusions:

    • Distinguishing between TN and basal-like breast cancer is critical.
    • Further understanding of their molecular and histopathological features is needed.
    • Identification criteria are essential for guiding treatment strategies and discovering novel therapeutic targets.