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Updated: Jun 27, 2026

An Inexpensive Adaptation of a Commercial Microwave Reactor for Solid Phase Peptide Synthesis
Published on: November 22, 2024
A room temperature ionic liquid as convenient solvent for the oxidative folding of conopeptides
Alesia A Miloslavina1, Enrico Leipold, Michael Kijas
1Center for Molecular Biomedicine, Department of Biochemistry, Friedrich Schiller University Jena, Jena, Germany.
Abstract:
We report the first example of conopeptide oxidation performed in a biocompatible ionic liquid, 1-ethyl-3-methylimidazolium acetate ([C(2)mim][OAc]), which enables the efficient formation of both hydrophilic and poorly water-soluble conotoxins compared with conventional methods. Moreover, the method features a high-concentration approach ultimately leading to higher yields at reduced separation effort.
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