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Updated: Jun 27, 2026
Microwave-assisted Functionalization of Poly(ethylene glycol) and On-resin Peptides for Use in Chain Polymerizations and Hydrogel Formation
Published on: October 29, 2013
Phenolic hydroxy groups incorporated for the peroxidase-catalyzed gelation of a carboxymethylcellulose support:
Yuko Ogushi1, Shinji Sakai, Koei Kawakami
1Department of Chemical Engineering, Faculty of Engineering, Kyushu University, 744 Motooka, Nishi-ku, Fukuoka 819-0395, Japan. yogushi@chem-eng.kyushu-u.ac.jp
Abstract:
The effect of Ph-OH group content on gelation time, mechanical properties, hydrophobicity, and cellular adhesiveness of hydrogels produced from carboxymethylcellulose derivatives is investigated. A higher Ph-OH group content induces faster gelation and yields more brittle and hydrophobic gels. After 4 h of seeding, a larger number of L929 fibroblasts adhere to the hydrogel of the CMC-Ph that contains 15.4 Ph-OH groups per 100 repeat units of uronic acid (97% adhesion rate) than to the gel of CMC-Ph with only 8.4 Ph-OH groups (62% adhesion rate). The results demonstrate that controlling the Ph-OH group content is an effective and useful way to control cellular adhesion and proliferation on the hydrogels, as well as gelation time and mechanical properties of the gels.
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