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Related Concept Videos

Stem Cell Niche01:26

Stem Cell Niche

The stem cell niche is the dynamic microenvironment where stem cells reside. Inside these niches, the cells may remain undifferentiated, undergo high self-renewal, or become lineage-specific progenitors. Stem cells coexist with other niche cells, such as stromal cells. They also interact closely with the ECM. Cell-cell and cell-matrix communication occur via adhesion molecules or soluble factors that signal the stem cells and determine their fate. Stromal cells also provide survival signals to...
Multipotency and Niche of Bulge Stem Cell01:06

Multipotency and Niche of Bulge Stem Cell

A hair follicle or HF is a small part of the skin that produces the hair shaft. Paul Gerson Unna was the first to observe a bulge in the human hair follicle's outer root sheath (ORS). The bulge is present between the sebaceous gland and the arrector pili muscle and is the niche for hair follicle stem cells (HFSCs). The bulge is also a niche for melanocyte stem cells, and their loss results in graying of hair. The HFSCs express Sox9 and Lhx2, which help them maintain stemness and prevent...
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...

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Updated: Jun 27, 2026

Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells
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Flow Cytometry Analysis of Murine Bone Marrow Hematopoietic Stem and Progenitor Cells and Stromal Niche Cells

Published on: September 28, 2022

The stem cell niche.

M R Walker1, K K Patel, T S Stappenbeck

  • 1Department of Pathology and Immunology, Washington University in St. Louis, St. Louis, MO 63110, USA.

The Journal of Pathology
|December 18, 2008
PubMed
Summary
This summary is machine-generated.

Adult stem cells reside in specialized microenvironments called niches, which regulate their behavior through physical contact and signaling molecules. This review explores stem cell niches across various organisms, from simple invertebrates to complex mammals.

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Area of Science:

  • Developmental Biology
  • Stem Cell Biology
  • Tissue Homeostasis

Background:

  • Adult organisms possess slowly-cycling stem cells crucial for tissue maintenance and repair.
  • These stem cells are regulated by their surrounding microenvironment, termed the stem cell niche.
  • Niche interactions involve physical contact and diffusible factors.

Purpose of the Study:

  • To review the concept and components of the stem cell niche.
  • To compare well-understood invertebrate stem cell niches with complex mammalian niches.
  • To highlight the regulatory mechanisms governing adult stem cell populations.

Main Methods:

  • Literature review and synthesis of existing research on stem cell niches.
  • Comparative analysis of stem cell niche structures and functions across different species.
  • Focus on germline stem cells in Caenorhabditis elegans and Drosophila melanogaster.
  • Examination of mammalian stem cell niches, including neural, epidermal, hematopoietic, and intestinal.

Main Results:

  • Stem cell niches are essential for maintaining tissue homeostasis and responding to injury.
  • Niche regulation involves both direct cell-cell interactions and secreted signaling molecules.
  • Invertebrate models provide foundational understanding, while mammalian niches present greater complexity.

Conclusions:

  • The stem cell niche is a critical determinant of stem cell function and tissue health.
  • Understanding niche biology is key to regenerative medicine and treating diseases.
  • Further research is needed to fully elucidate complex mammalian stem cell niche interactions.