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Updated: Jun 27, 2026

Identification of Mouse and Human Antibody Repertoires by Next-Generation Sequencing
08:51

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Published on: March 15, 2019

Conserved amino acid networks involved in antibody variable domain interactions

Norman Wang1, William F Smith, Brian R Miller

  • 1Biogen Idec, San Diego, California 92122, USA.

Proteins
|December 18, 2008
PubMed
Summary

Researchers identified conserved amino acid networks in antibody variable regions (V(H) and V(L)) to improve engineered antibody therapeutics. These networks, particularly at the V(H)-V(L) interface, are crucial for antibody stability and function.

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