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Oncocytic metaplasia of the pharynx
G V Morin1, E C Shank, L P Burgess
1Otolaryngology-Head and Neck Surgery Service, Walter Reed Army Medical Center, Washington, D.C.
Abstract:
Oncocytic metaplasia of the pharynx has been infrequently described, with only two previous cases in the literature. With the advent of panendoscopy during the last decade, however, a better understanding of this histopathologic diagnosis is desirable. Thirty-three cases are reviewed, with thirty occurring in the nasopharynx. This was most commonly discovered as an unrelated finding during endoscopic evaluation of a head and neck mass or malignancy in twenty-two patients, either histologically after random biopsy or after biopsy of small but visible lesions. An additional eight cases manifested otitis media or eustachian tube dysfunction. The histology, terminology, and benign clinical nature of these lesions are discussed.
Insights
Oncocytic metaplasia, a rare pharyngeal condition, is increasingly identified via panendoscopy, often incidentally. Most cases occur in the nasopharynx and are benign.
Area of Science:
- Otolaryngology
- Head and Neck Surgery
- Pathology
Background:
- Oncocytic metaplasia of the pharynx is a rare condition with limited literature.
- Advancements in panendoscopy necessitate a clearer understanding of this histopathologic diagnosis.
Observation:
- A review of 33 cases of pharyngeal oncocytic metaplasia was conducted.
- Thirty of these cases (91%) occurred in the nasopharynx.
- The condition was frequently an incidental finding during endoscopic evaluation for head and neck masses or malignancies.
Findings:
- Oncocytic metaplasia was discovered via random biopsy or biopsy of small lesions in 22 patients.
- Eight cases presented with symptoms of otitis media or eustachian tube dysfunction.
- The study discusses the histology, terminology, and generally benign clinical behavior of these lesions.
Implications:
- Increased identification of oncocytic metaplasia is expected with routine panendoscopy.
- Understanding its benign nature is crucial for accurate diagnosis and patient management.
- Further research into the etiology and specific clinical implications is warranted.