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Studies on antimicrobial activity of Perionyx excavatus

S Ahmed John1, N Packialakshmi

  • 1Molecular Genetics Research Laboratory, Post Graduate and Research Department of Botany, Jamal Mohamed College, Trichirappali-620020, India.

Pakistan Journal of Biological Sciences : PJBS
|December 19, 2008
PubMed

Insights

This study evaluated vermiextract

Area of Science:

  • Microbiology and Pharmacology
  • Natural Product Research

Background:

  • Urinary tract infections (UTIs) are common, particularly in children, with Proteus species being a significant causative agent.
  • Antimicrobial resistance necessitates the exploration of novel therapeutic agents.

Purpose of the Study:

  • To assess the antimicrobial efficacy of vermiextract against human pathogenic microorganisms.
  • To identify specific bacterial strains susceptible to vermiextract, focusing on UTI pathogens.

Main Methods:

  • Antimicrobial activity screening using the disc diffusion method.
  • Determination of Minimum Inhibitory Concentration (MIC) via microdilution.

Main Results:

  • Vermiextract demonstrated antimicrobial activity against E. coli, Proteus, Providencia, and Morganella species.
  • Zones of inhibition ranged from 17-19 mm at 1 mg concentration.
  • Vermiextract exhibited the highest efficacy against Proteus species.

Conclusions:

  • Vermiextract possesses significant antimicrobial properties, particularly against Proteus species.
  • This natural extract shows potential as a therapeutic agent for combating UTIs.

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