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Updated: Jun 27, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Identification of novel HCV RNA-dependent RNA polymerase inhibitors using pharmacophore-guided virtual screening
Jinyoung Kim1, Ki-sun Kim, Dong-Eun Kim
1Department of Bioscience and Biotechnology, Konkuk University, Seoul, Korea.
Abstract:
We performed pharmacophore-guided virtual screening experiments using FlexX-Pharm to identify novel inhibitors of hepatitis C virus RNA-dependent RNA polymerase. Pharmacophore model generated from our previous analysis of the binding modes as well as structure-based three-dimensional quantitative structure-activity relationship studies of aryl diketoacid analogues was used. In pharmacophore-guided virtual screening study, among 37 447 compounds in LeadQuest chemical library, 40 compounds were selected as novel candidates of hepatitis C virus RNA-dependent RNA polymerase inhibitors, and their biological activities were evaluated. Especially, T29 was chosen for further development.
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