Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin studies.
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within the...
Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Schizophrenia01:17

Schizophrenia

Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those diagnosed.
Protein-protein Interfaces02:04

Protein-protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Left Atrial Appendage Closure vs Direct Oral Anticoagulants in Atrial Fibrillation: Meta-Analysis of Randomized Trials.

JACC. Advances·2026
Same author

A retrospective study comparing oral celecoxib combined with flurbiprofen hydrogel patch versus oral celecoxib therapy for lateral epicondylitis: real-world analysis of the anti-inflammatory and analgesic efficacy and safety.

Frontiers in pharmacology·2026
Same author

Clinical implementation of 3D deep learning techniques in predicting touch-up lesions for atrial fibrillation patients undergoing cryoablation.

International journal of cardiology. Heart & vasculature·2026
Same author

Screening of Atrial Fibrillation/Arrhythmia Events in Patients With Abnormal ECHOcardiographic Parameters: The Randomized, Prospective SAFE-ECHO Study Design and Rationale.

The American journal of cardiology·2026
Same author

Risk-Guided Atrial Fibrillation Screening in the Era of Artificial Intelligence.

Journal of the American College of Cardiology·2026
Same author

The Associations Between Heart Rate, Deformational Echocardiographic Parameters, and Outcomes in Patients With Atrial Fibrillation.

JACC. Asia·2026
Same journal

OpenIMC: an open-source platform for analyzing single-cell and spatial proteomics by imaging mass cytometry.

BMC bioinformatics·2026
Same journal

NAP: an open source pipeline for cross-domain microbiome profiling using Nanopore sequencing-derived amplicon data.

BMC bioinformatics·2026
Same journal

SurvGME: an R package for survival analysis with graphical and measurement error models.

BMC bioinformatics·2026
Same journal

SimMapNet: a Bayesian framework for gene regulatory network inference using gene ontology similarities as external hint.

BMC bioinformatics·2026
Same journal

Dual channel drug-drug interactions extraction based on cross attention.

BMC bioinformatics·2026
Same journal

FeSseqdb: a curated sequence-level database and interpretable machine learning framework for identifying iron-sulfur proteins.

BMC bioinformatics·2026
See all related articles

Related Experiment Video

Updated: Jun 27, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

A protein interaction based model for schizophrenia study.

Pei-Chun Hsu1, Ueng-Cheng Yang, Kuan-Hui Shih

  • 1Institute of Biomedical Informatics, National Yang-Ming University, Taiwan. pchsu@ym.edu.tw

BMC Bioinformatics
|December 19, 2008
PubMed
Summary
This summary is machine-generated.

Schizophrenia genetics involve complex gene interactions. This study identifies protein networks, suggesting NRG1 and CACNG2 gene interactions may influence glutamatergic signaling and calcium influx, potentially contributing to schizophrenia pathogenesis.

More Related Videos

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

Related Experiment Videos

Last Updated: Jun 27, 2026

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra
05:14

Standardized Data Acquisition for Neuromelanin-Sensitive Magnetic Resonance Imaging of the Substantia Nigra

Published on: September 8, 2021

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation
07:57

Quantification of Protein Interaction Network Dynamics using Multiplexed Co-Immunoprecipitation

Published on: August 21, 2019

Area of Science:

  • Neuroscience
  • Genetics
  • Bioinformatics

Background:

  • Schizophrenia is a complex, highly heritable disease influenced by genetic and environmental factors.
  • Identifying specific gene combinations contributing to schizophrenia pathogenesis remains a challenge.
  • Previous studies have identified candidate genes through various approaches, but their collective effect is not well understood.

Purpose of the Study:

  • To investigate the protein-protein interaction (PPI) network of schizophrenia candidate genes.
  • To identify potential pathogenic mechanisms by analyzing gene combinations and their interactions.
  • To explore the role of identified gene modules in synaptic transmission and signal transduction.

Main Methods:

  • Constructed a PPI sub-network using the nearest neighbors of 36 reported schizophrenia candidate genes.
  • Identified protein interaction modules using pairwise distance analysis within the sub-network.
  • Utilized gene ontology annotation and co-expression analysis to interpret the functional roles of identified modules.

Main Results:

  • The PPI sub-network revealed a significant clustering of candidate gene proteins, indicating interconnectedness.
  • Two major protein interaction modules were identified, potentially involved in synaptic transmission and signal transduction.
  • The interaction between NRG1 and CACNG2 genes within the synaptic transmission module was supported by co-expression analysis.

Conclusions:

  • The NRG1-CACNG2 interaction may modulate glutamatergic signaling through NMDAR and AMPA receptor regulation.
  • This interaction could affect calcium ion (Ca2+) influx, potentially representing a disease mechanism in schizophrenia.
  • PPI network analysis combined with co-expression data offers an efficient approach to elucidate pathogenetic mechanisms in heritable diseases.