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Related Experiment Video

Updated: Jun 27, 2026

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
05:28

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Published on: October 11, 2024

Impact of early applied upper limb stimulation: the EXPLICIT-stroke programme design.

Gert Kwakkel1, Carel G M Meskers, Erwin E van Wegen

  • 1Dept. Rehabilitation Medicine, VU University Medical Centre, Amsterdam, The Netherlands. g.kwakkel@vumc.nl

BMC Neurology
|December 19, 2008
PubMed
Summary

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Early intensive rehabilitation, including modified Constraint-Induced Movement Therapy (mCIMT) and EMG-triggered Neuro-Muscular Stimulation (EMG-NMS), can improve upper limb function after stroke. This research explores neuroplasticity and recovery mechanisms to optimize post-stroke care.

Area of Science:

  • Neuroscience
  • Rehabilitation Medicine
  • Clinical Trials

Background:

  • Functional recovery of the paretic upper limb post-stroke is often considered time-limited to the first month.
  • Intensive, task-oriented rehabilitation within this early window is recommended.

Purpose of the Study:

  • To explore mechanisms of post-stroke upper limb recovery.
  • To investigate the effects of early modified Constraint-Induced Movement Therapy (mCIMT) and EMG-triggered Neuro-Muscular Stimulation (EMG-NMS).

Main Methods:

  • 180 acute ischemic stroke patients stratified by prognosis (favourable/poor).
  • Randomized controlled trials comparing mCIMT/EMG-NMS with usual care.
  • Primary outcome: Action Research Arm Test (ARAT) assessed up to 26 weeks.

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Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial
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Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial

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Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot
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Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot

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Related Experiment Videos

Last Updated: Jun 27, 2026

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients
05:28

Application of a Dual Upper Limb Task-Oriented Robotic System for the Functional Recovery of the Upper Limb in Stroke Patients

Published on: October 11, 2024

Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial
04:38

Application of Bedside Lower Extremity Rehabilitation Robots in Stroke Rehabilitation: A Randomized Controlled Trial

Published on: November 28, 2025

Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot
04:49

Enhancing Upper Limb Function and Motor Skills Post-Stroke Through an Upper Limb Rehabilitation Robot

Published on: September 6, 2024

Main Results:

  • Exploration of neuroplasticity, compensatory movements, and neuromechanics using TMS, kinematics, and robotics.
  • fMRI used to assess neural changes at baseline, 5, and 26 weeks post-stroke.

Conclusions:

  • EXPLICIT-stroke investigates early intensive interventions for dexterity recovery.
  • Aims to determine if improvements stem from neural repair (restitution) or behavioral compensation (substitution).