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Related Concept Videos

Treatment Resistent Cancers02:56

Treatment Resistent Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
Treatment Resistant Cancers02:56

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
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[Everolimus (RAD001) and solid tumours: a 2008 summary].

A Lévy1, L Albiges Sauvin, C Massard

  • 1Département de médecine, service des innovations thérapeutiques précoces (SITEP), Institut Gustave-Roussy, Villejuif.

Bulletin Du Cancer
|December 19, 2008
PubMed
Summary

Everolimus, an inhibitor of mammalian target of rapamycin (mTOR), demonstrates significant anti-angiogenic and anti-proliferative effects in preclinical cancer models. Clinical data show antitumor activity, particularly in metastatic renal cell cancer, with good tolerability.

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Published on: March 20, 2021

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Mammalian target of rapamycin (mTOR) is a key regulator of cell growth and proliferation.
  • mTOR signaling is implicated in various human cancers.
  • Everolimus is an oral mTOR inhibitor derived from rapamycin.

Purpose of the Study:

  • To review preclinical data and clinical results of everolimus (RAD001).
  • To evaluate the anti-angiogenic and anti-proliferative activity of everolimus.
  • To discuss the tolerability and antitumor effects of everolimus in malignancies.

Main Methods:

  • Review of preclinical studies on human tumor cell lines and xenograft models.
  • Analysis of clinical trial data for everolimus in cancer patients.
  • Assessment of adverse events and antitumor responses.

Main Results:

  • Everolimus exhibits significant anti-angiogenic and anti-proliferative activity in preclinical models.
  • Clinical studies demonstrate antitumor activity, including tumor regression and stable disease.
  • Everolimus is generally well-tolerated, with manageable side effects.

Conclusions:

  • Everolimus shows promising antitumor activity across various malignancies, especially metastatic renal cell cancer.
  • The compound is well-tolerated, with reversible adverse events.
  • Further clinical development of everolimus is warranted.