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Related Concept Videos

Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
Formation of Muscle Fibers from Myoblasts01:13

Formation of Muscle Fibers from Myoblasts

De novo myogenesis, or the formation of muscle fibers, begins during the early embryonic stages. The skeletal muscle is formed from somites– blocks of embryonic cell layers. The somites are further divided into dermatomes, myotomes, sclerotomes, and syndetomes. Among these, the myotomes give rise to muscle fibers.
Muscle progenitor cells (MPCs) are formed from the myotomes. MPCs express genes that encode the transcription factors Pax3 and Pax7. Along with Pax 3/7, other transcription factors...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx as...

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Related Experiment Video

Updated: Jun 27, 2026

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
06:51

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

microRNAs and muscle disorders.

Jian-Fu Chen1, Thomas E Callis, Da-Zhi Wang

  • 1Department of Cell and Developmental Biology, University of North Carolina, Chapel Hill, NC 27599-7126, USA.

Journal of Cell Science
|December 19, 2008
PubMed
Summary

MicroRNAs (miRNAs) are small RNAs regulating gene expression. Studies show miRNAs are crucial for muscle development and function, offering potential as disease markers and therapeutic targets.

Area of Science:

  • Molecular Biology
  • Genetics
  • Biochemistry

Background:

  • MicroRNAs (miRNAs) are conserved non-coding RNAs regulating gene expression post-transcriptionally.
  • They play roles in cell proliferation, differentiation, and apoptosis.
  • miRNAs are present in muscle tissues and linked to muscle disorders.

Purpose of the Study:

  • To investigate the role of miRNAs in muscle development and function.
  • To explore the potential of miRNAs as diagnostic markers and therapeutic targets for muscle diseases.

Main Methods:

  • Review of genetic studies on miRNA function in cardiogenesis and muscle disorders.
  • Analysis of research involving conditional inhibition of miRNA maturation in mouse models.

Main Results:

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Methods to Assess Subcellular Compartments of Muscle in C. elegans
10:13

Methods to Assess Subcellular Compartments of Muscle in C. elegans

Published on: November 13, 2014

Related Experiment Videos

Last Updated: Jun 27, 2026

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents
06:51

Systemic Delivery of MicroRNA Using Recombinant Adeno-associated Virus Serotype 9 to Treat Neuromuscular Diseases in Rodents

Published on: August 10, 2018

Methods to Assess Subcellular Compartments of Muscle in C. elegans
10:13

Methods to Assess Subcellular Compartments of Muscle in C. elegans

Published on: November 13, 2014

  • Specific miRNAs have distinct roles in cardiac development and electrical conduction.
  • Conditional inhibition of miRNA maturation impairs cardiac and skeletal muscle development and function.
  • Dysregulated miRNA expression correlates with muscle-related pathologies.

Conclusions:

  • miRNAs are essential regulators of muscle development and function.
  • These findings highlight miRNAs as key players in muscle biology and pathology.
  • miRNAs represent promising diagnostic and therapeutic targets for muscle diseases.