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Related Concept Videos

Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Induced Pluripotent Stem Cells01:06

Induced Pluripotent Stem Cells

Stem cells are undifferentiated cells that divide and produce different cell types. Ordinarily, cells that have differentiated into a specific cell type are terminally differentiated; however, scientists have found a way to reprogram these mature cells so that they dedifferentiate and return to an unspecialized, proliferative state. These cells are pluripotent like embryonic stem cells—able to produce all cell types—and are called induced pluripotent stem cells (iPSCs).
Somatic cells are...
Adult Stem Cells01:33

Adult Stem Cells

Stem cells are undifferentiated cells that divide and produce more stem cells or progenitor cells that differentiate into mature, specialized cell types. All the cells in the body are generated from stem cells in the early embryo, but small populations of stem cells are also present in many adult tissues including the bone marrow, brain, skin, and gut. These adult stem cells typically produce the various cell types found in that tissue—to replace cells that are damaged or to continuously renew...

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A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells
09:05

A Novel Clinical Grade Isolation Method for Human Kidney Perivascular Stromal Cells

Published on: August 7, 2017

Stem cell therapy for the kidney?

Rachel Zubko1, William Frishman

  • 1Department of Medicine, Oregon Health Sciences University, Portland, OR, USA.

American Journal of Therapeutics
|December 19, 2008
PubMed
Summary
This summary is machine-generated.

Bone marrow stem cells show promise for kidney regeneration and treating chronic kidney disease. Their paracrine effects improve renal function, with clinical trials for acute kidney injury on the horizon.

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Last Updated: Jun 27, 2026

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09:00

Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology

Published on: March 27, 2018

Area of Science:

  • Nephrology
  • Regenerative Medicine
  • Stem Cell Biology

Background:

  • The kidney possesses regenerative capacity but often succumbs to progressive scarring, leading to chronic kidney disease.
  • Current renal replacement therapies like dialysis and transplantation are limited.
  • Stem cell therapy offers a potential avenue for preventing and treating kidney diseases.

Purpose of the Study:

  • To explore the potential of bone marrow-derived stem cells in renal regeneration and treatment.
  • To evaluate the role of stem cells in mitigating kidney injury and disease progression.

Main Methods:

  • Review of existing literature on renal regeneration and stem cell research.
  • Analysis of studies investigating bone marrow stem cells in animal models of kidney injury.
  • Consideration of preliminary clinical trial data and future research directions.

Main Results:

  • Bone marrow stem cells demonstrate potential in kidney regeneration, primarily through paracrine effects that improve renal function.
  • While direct transdifferentiation and cell fusion roles are minor in mouse models, paracrine mechanisms significantly enhance recovery after acute ischemia.
  • Animal studies highlight the versatility of stem cell therapy for renal applications.

Conclusions:

  • Bone marrow-derived stem cells hold significant promise for kidney regeneration and ameliorating renal disease.
  • Further basic science research into renal regeneration mechanisms is crucial.
  • Clinical trials investigating bone marrow mesenchymal cells for acute kidney injury protection are anticipated, paving the way for broader applications in complex patient populations.