Related Experiment Video
Updated: Jun 27, 2026
Isolation, Expansion, and Adipogenic Induction of CD34+CD31+ Endothelial Cells from Human Omental and Subcutaneous Adipose Tissue
Published on: July 17, 2018
Longitudinal changes in high molecular weight serum adiponectin levels in healthy infants
Satoshi Hibino1, Kazuo Itabashi, Yuya Nakano
1Department of Pediatrics, Showa University School of Medicine, Tokyo 142-8666, Japan.
Insights
High molecular weight adiponectin (HMW-ad) levels in infants decrease significantly by 12 months. Cord blood HMW-ad levels predict infant levels, suggesting prenatal regulation.
Area of Science:
- Pediatrics
- Endocrinology
- Metabolic Health
Background:
- Adiponectin, particularly high molecular weight adiponectin (HMW-ad), plays a crucial role in metabolic regulation.
- Understanding the factors influencing HMW-ad levels in early life is essential for predicting long-term metabolic health.
- Longitudinal data on HMW-ad during infancy is limited.
Purpose of the Study:
- To investigate the longitudinal changes in serum HMW-ad levels from birth to 12 months of age in healthy infants.
- To identify factors associated with HMW-ad levels during the first year of life.
Main Methods:
- A longitudinal study measuring total adiponectin, HMW-ad, and leptin in 56 healthy infants from birth to 12 months.
- Serum samples were collected at birth, 6 months, and 12 months.
- Multiple regression analysis was used to determine predictive factors for HMW-ad levels.
Main Results:
- Serum HMW-ad levels showed a strong positive correlation with total adiponectin levels (R2 = 0.93).
- HMW-ad levels at 12 months (7.7 ± 0.5 μg/mL) were significantly lower than at birth (13.7 ± 0.9 μg/mL) and 6 months (13.3 ± 0.8 μg/mL).
- Multiple regression analysis indicated that only cord blood HMW-ad levels significantly predicted HMW-ad levels at 12 months (β = 0.680).
Conclusions:
- Postnatal HMW-ad production during infancy may be regulated prenatally.
- Cord blood HMW-ad levels are a key determinant of HMW-ad levels in the first year of life.
- Further research is needed to explore the role of cord blood HMW-ad in metabolic syndrome development.
Abstract:
To determine the factors associated with high molecular weight adiponectin (HMW-ad) levels during the first year of life, the longitudinal changes in serum HMW-ad were investigated from birth to 12 mo of age. The total adiponectin levels, HMW-ad, and leptin were measured longitudinally from birth to 12 mo of age in 56 healthy infants (>or=35 wk of gestation). Serum HMW-ad levels were positively correlated with total adiponectin levels (R2 = 0.93, p < 0.0001). Serum HMW-ad levels at birth, six, and 12 mo were 13.7 +/- 0.9 (mean +/- SE), 13.3 +/- 0.8, and 7.7 +/- 0.5 microg/mL, respectively. The levels at 12 mo were significantly lower than those at birth and 6 mo, respectively. In a multiple regression analysis, the HMW-ad levels at 12 mo were found to be related only to cord blood HMW-ad levels (beta = 0.680, p < 0.001) and not to any other factors. These results imply that postnatal production of HMW-ad at least during infancy may be regulated before birth. Further study is necessary to determine whether cord blood HMW-ad has an effect and whether it is involved in the development of metabolic syndrome.
