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UP states protect ongoing cortical activity from thalamic inputs.

Brendon O Watson¹, Jason N MacLean, Rafael Yuste

¹Howard Hughes Medical Institute, Department of Biological Sciences, Columbia University, New York, NY, USA. bow4@columbia.edu

|December 19, 2008

Summary

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Cortical neurons alternate between UP and DOWN states. Thalamic stimulation can trigger UP states from DOWN states, but UP states are insensitive to thalamic input during ongoing cortical activity.

Area of Science:

Neuroscience
Computational Neuroscience

Background:

Cortical neurons exhibit spontaneous UP and DOWN states.
UP states correlate with neuronal firing important for information processing.

Purpose of the Study:

To investigate the interaction between thalamic inputs and cortical UP state activity.
To understand how thalamic stimulation affects neuronal dynamics during different cortical states.

Main Methods:

Used calcium imaging and whole-cell recordings in mouse somatosensory thalamocortical slices.
Stimulated thalamic inputs during both DOWN and UP states.

Main Results:

Thalamic stimulation during DOWN states induced synchronized UP states.
Thalamic stimulation during UP states did not alter subthreshold membrane dynamics or neuronal firing patterns.

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Reduced postsynaptic potentials (PSPs) and input resistance during UP states were observed.

Conclusions:

Cortical UP states are mechanistically insensitive to thalamic inputs.
Ongoing cortical dynamics during UP states are not modulated by thalamic activity.