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Combination Therapies and Personalized Medicine

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Related Experiment Video

Updated: Jun 27, 2026

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors
08:08

Quantitative Mass Spectrometric Profiling of Cancer-cell Proteomes Derived From Liquid and Solid Tumors

Published on: February 27, 2015

Understanding tumor profiling and assessing treatment.

David M Hyams1

  • 1Comprehensive Cancer Center, Desert Regional Medical Center, Palm Springs, California, USA.

Managed Care (Langhorne, Pa.)
|December 20, 2008
PubMed
Summary
This summary is machine-generated.

Gene expression profiling provides insights into tumor cell communication and behavior. The development of the 70-gene MammaPrint assay paved the way for newer diagnostic tools like the 21-gene Oncotype DX assay for breast cancer.

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Area of Science:

  • Molecular biology
  • Genomics
  • Cancer research

Background:

  • Gene expression profiling offers a window into tumor cell genetic communication and behavior.
  • The foundational 70-gene MammaPrint assay development was crucial for advancing diagnostic technologies.
  • Established assays guide clinical decisions for specific breast cancer subtypes.

Purpose of the Study:

  • To highlight the evolution of gene expression profiling in breast cancer diagnostics.
  • To underscore the significance of established genomic assays in clinical practice.
  • To contextualize the role of Oncotype DX in current breast cancer care standards.

Main Methods:

  • Review of gene expression profiling technologies.
  • Analysis of historical data from the 70-gene assay (MammaPrint) development.
  • Examination of current clinical recommendations for genomic assays.

Main Results:

  • Gene expression profiling is a key method for understanding tumor cell genetics.
  • The 70-gene assay (MammaPrint) was a significant precursor to modern genomic tests.
  • The 21-gene assay (Oncotype DX) is now a standard of care for specific breast cancer patients.

Conclusions:

  • Genomic assays have advanced breast cancer diagnosis and treatment stratification.
  • The progression from MammaPrint to Oncotype DX demonstrates significant progress in personalized oncology.
  • Oncotype DX represents a validated, standard-of-care tool for early-stage, ER-positive breast cancer management.