Tigecycline: in community-acquired pneumonia

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P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives
10:26

P. aeruginosa Infected 3D Co-Culture of Bronchial Epithelial Cells and Macrophages at Air-Liquid Interface for Preclinical Evaluation of Anti-Infectives

Published on: June 15, 2020

Kate McKeage1, Gillian M Keating

  • 1Wolters Kluwer Health, Adis, Auckland, New Zealand. demail@adis.co.nz

Drugs
|December 20, 2008
PubMed

Insights

Tigecycline, an antibacterial, is effective for community-acquired pneumonia (CAP) in adults. Clinical trials show it is not inferior to levofloxacin, offering a new treatment option for CAP.

Area of Science:

  • Pharmacology
  • Infectious Diseases
  • Clinical Microbiology

Background:

  • Tigecycline is a first-in-class glycylcycline antibiotic designed to overcome tetracycline resistance mechanisms.
  • Currently approved for complicated intra-abdominal and skin infections, its efficacy for community-acquired pneumonia (CAP) in adults is under evaluation.
  • Tigecycline exhibits broad-spectrum activity against common respiratory pathogens and possesses favorable pharmacokinetic properties, including a prolonged post-antibiotic effect and lung tissue penetration.

Purpose of the Study:

  • To assess the efficacy and tolerability of tigecycline in the treatment of hospitalized adult patients with community-acquired pneumonia (CAP).

Main Methods:

  • Two well-designed Phase III clinical studies were conducted.
  • Hospitalized adult patients with CAP were treated with tigecycline (100 mg initially, then 50 mg every 12 hours for 7-14 days) or levofloxacin.
  • Efficacy was evaluated based on clinical cure rates in clinically evaluable and modified intent-to-treat populations.

Main Results:

  • Tigecycline demonstrated non-inferiority to levofloxacin in treating CAP.
  • Clinical cure rates for tigecycline were 89.7% (clinically evaluable) and 81.0% (modified intent-to-treat).
  • Tigecycline was generally well tolerated by patients with CAP.

Conclusions:

  • Tigecycline is a safe and effective treatment option for hospitalized adult patients with community-acquired pneumonia.
  • The drug's efficacy and tolerability profile support its use as an alternative to levofloxacin for CAP.
  • Tigecycline's activity against resistant pathogens makes it a valuable addition to the treatment armamentarium for respiratory tract infections.

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