Related Experiment Video
Updated: Jun 27, 2026

Real-time Evaluation of Absolute, Cytosolic, Free Ca2+ and Corresponding Contractility in Isolated, Pressurized Lymph Vessels
Published on: March 22, 2024
Arterial regulators taken up by lymphatics
Carrie J Shawber1, Jan Kitajewski
1Department of Obstetrics/Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.
Abstract:
We present three examples of key genes that function in arterial specification that have recently been implicated in lymphatic development; ephrinB2, FoxC2, and Notch. In arterial cell fate determination, Foxc2 regulates both Notch and Notch ligand expression. In turn, Notch signal activation in arteries drives expression of ephrinB2. It will be interesting to determine if the regulatory relationships between these pathways found in arterial development are relevant to understanding lymphatic development, that is, we ask whether arterial regulators are also key regulators of lymphatic development.
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