Developmental angiogenesis of the central nervous system
Related Experiment Video
Updated: Jun 27, 2026

Assessment of Vascular Regeneration in the CNS Using the Mouse Retina
Published on: June 23, 2014
Michael R Mancuso1, Frank Kuhnert, Calvin J Kuo
1Stanford University School of Medicine. Division of Hematology, Stanford, CA.
Abstract:
The vasculature of the central nervous system (CNS) is highly specialized with a blood-brain-barrier, reciprocal neuroepithelial-endothelial cell interactions and extensive pericyte coverage. Developmentally, numerous important signaling pathways participate in CNS angiogenesis to orchestrate the precise timing and spatial arrangement of the complex CNS vascular network. From a therapeutic standpoint, the CNS vasculature has attracted increased attention since many human ailments, such as stroke, retinopathy, cancer and autoimmune disease are intimately associated with the biology of CNS blood vessels. This review focuses on growth factor pathways that have been shown to be important in developmental CNS vascularization through studies of mouse genetic models and human diseases.
Related Concept Videos
Mechanism of Angiogenesis
Regulation of Angiogenesis and Blood Supply
Development of Blood Vessels
The initial formation of this system is facilitated by the small amount of yolk present in the ovum and yolk sac. Blood vessels originate from...
Neurulation
Neurogenesis and Regeneration of Nervous Tissue

