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Vaccinations

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Immune Response Against Viral Pathogens

Immune Response Against Viral Pathogens

The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...

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Related Experiment Video

Updated: Jun 27, 2026

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

Published on: December 24, 2016

Dendritic cell-based human immunodeficiency virus vaccine.

¹Department of Infectious Diseases, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA. rinaldo@pitt.edu

Journal of Internal Medicine

|December 20, 2008

Summary

Dendritic cell (DC) immunotherapy shows promise for enhancing T-cell immunity against HIV. Research guides safe and effective DC-based strategies to improve HIV control in patients on antiretroviral therapy.

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Published on: September 1, 2015

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Last Updated: Jun 27, 2026

Generation of Human Monocyte-derived Dendritic Cells from Whole Blood

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Published on: December 24, 2016

A Tetracycline-regulated Cell Line Produces High-titer Lentiviral Vectors that Specifically Target Dendritic Cells

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Assessing the Innate Sensing of HIV-1 Infected CD4+ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Assessing the Innate Sensing of HIV-1 Infected CD4⁺ T Cells by Plasmacytoid Dendritic Cells Using an Ex vivo Co-culture System.

Published on: September 1, 2015

Area of Science:

Immunology
Virology
Biotechnology

Background:

Dendritic cells (DCs) are potent inducers of T-cell immunity.
DCs are being explored as biological agents for HIV immunotherapies.
Current strategies involve ex vivo DC-HIV antigen administration in clinical trials.

Purpose of the Study:

To define safe and effective strategies for enhancing HIV control.
To guide DC immunotherapy development for HIV-infected patients.
To augment T-cell immunity against HIV infection.

Main Methods:

Preclinical studies inform DC type, HIV antigen form, maturation methods, and administration routes.
Clinical trials administer ex vivo DC-HIV antigen preparations.
In vivo DC targeting with HIV antigens is an emerging approach.

Main Results:

DC immunotherapy is being evaluated for safety and efficacy in HIV-infected individuals.
Preclinical data are crucial for optimizing DC immunotherapy protocols.
Research aims to improve anti-HIV immune function and viral replication control.

Conclusions:

Dendritic cell immunotherapy holds potential for managing HIV infection.
Optimizing DC-based strategies is essential for successful HIV treatment.
Further research is needed to refine in vivo and ex vivo approaches for enhanced HIV control.