Morphological changes of poly(DI-lactide-co-glycolide) nano-particles containing ascorbic acid during in vitro
M Stevanović1, B Jordović, D Uskoković
1Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia. magir@eunet.yu
Journal of Microscopy
|December 20, 2008
Abstract:
Poly(DL-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(DL-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy.
