Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 27, 2026

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Particle size analysis: 90Y and 99mTc-labelled colloids.

D Janković1, T Maksin, D Djokić

  • 1Vinca Institute of Nuclear Sciences, 11000 Belgrade, Serbia. drinaj@vin.bg.ac.yu

Journal of Microscopy
|December 20, 2008
PubMed
Summary

Particle size is crucial for radiopharmaceuticals. Transmission electron microscopy (TEM) is more reliable than photon correlation spectroscopy (PCS) for accurately measuring radiocolloid particle size in nuclear medicine.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Peripheral regional anesthesia and analgesia: "the magnificent seven" for training].

Die Anaesthesiologie·2026
Same author

HEMORRHAGIC PHEOCHROMOCYTOMA AND SEVERE CAROTID STENOSIS: A MULTIDISCIPLINARY APPROACH TO SURGICAL PRIORITIZATION.

Acta endocrinologica (Bucharest, Romania : 2005)·2025
Same author

IODINATED CONTRAST MEDIA INDUCED THYROID STORM AND ACUTE CORONARY SYNDROME: A CASE REPORT.

Acta endocrinologica (Bucharest, Romania : 2005)·2025
Same author

Clinical symptoms and surgical outcome of colloid cysts of the third ventricle: A multicenter retrospective study.

Brain & spine·2025
Same author

Computational insights into the redox properties and electronic structures of [Tc=O]<sup>3+</sup> complexes: Implications for <sup>99m</sup>Tc-radiopharmaceuticals.

Journal of molecular graphics & modelling·2025
Same author

The influence of the tooth preparation finish line position on the expression of matrix metalloproteinase-9 and the presence of periodontopathogens in the gingival crevicular fluid.

European review for medical and pharmacological sciences·2023

Area of Science:

  • Nuclear Medicine
  • Radiopharmaceutical Science
  • Materials Science

Background:

  • Colloidal particle size is a critical factor in selecting radiopharmaceuticals for diagnostic and therapeutic applications.
  • Accurate particle-size determination is essential for predicting the behavior and efficacy of radiocolloids.

Purpose of the Study:

  • To determine the particle-size distribution of (90)Y- and (99m)Tc-labeled antimony trisulfide (Sb(2)S(3)) and tin colloids (Sn-colloid).
  • To compare the effectiveness of Photon Correlation Spectroscopy (PCS) and Transmission Electron Microscopy (TEM) in radiocolloid particle-sizing.

Main Methods:

  • Utilized Photon Correlation Spectroscopy (PCS) to measure particle-size distribution.
  • Employed Transmission Electron Microscopy (TEM) for high-resolution particle-size analysis.

More Related Videos

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Published on: November 20, 2018

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures
10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

Published on: May 20, 2014

Related Experiment Videos

Last Updated: Jun 27, 2026

Synthesis and Characterization of Supramolecular Colloids
09:26

Synthesis and Characterization of Supramolecular Colloids

Published on: April 22, 2016

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging
07:26

Synthesis of 68Ga Core-doped Iron Oxide Nanoparticles for Dual Positron Emission Tomography /(T1)Magnetic Resonance Imaging

Published on: November 20, 2018

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures
10:56

Confocal Imaging of Confined Quiescent and Flowing Colloid-polymer Mixtures

Published on: May 20, 2014

  • Analyzed (90)Y-Sb(2)S(3), (99m)Tc-Sb(2)S(3), (90)Y-Sn colloid, and (99m)Tc-Sn colloid.

    • Main Results:

    • PCS measurements for (90)Y-Sb(2)S(3) and (99m)Tc-Sb(2)S(3) yielded diameters of 28.92 ± 0.14 nm and 35.61 ± 0.11 nm, respectively.
    • TEM measurements for (90)Y-Sb(2)S(3) showed a mean diameter of 14.33 ± 0.09 nm.
    • PCS revealed bimodal size distributions for (90)Y-Sn colloid (d(v(max1)) = 805 nm, d(v(max2)) = 2590 nm) and a predominant size of ~910 nm for (99m)Tc-Sn colloid.
    • Significant discrepancies were observed between TEM and PCS mean diameter measurements for (90)Y-labeled Sb(2)S(3) and Sn colloid.

    Conclusions:

    • Transmission Electron Microscopy (TEM) offers superior resolution and reliability for radiocolloid particle-sizing compared to Photon Correlation Spectroscopy (PCS).
    • TEM is the preferred method for accurate size characterization of radiocolloids used in nuclear medicine.