Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Notch Signaling Pathway

Notch Signaling Pathway

The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not until 1985...

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Role Of Notch Signalling In Intestinal Stem Cell Renewal

Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
Direct cell-to-cell contact is needed for the activation of Notch signaling. The signal is initiated when a notch ligand binds to a receptor on an adjacent cell, also...

Neurulation

Neurulation

Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the anterior...

Disorders of the Nervous Tissue

Disorders of the Nervous Tissue

Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...

Neurogenesis and Regeneration of Nervous Tissue

Neurogenesis and Regeneration of Nervous Tissue

In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrating androgen signaling tumor dependency with host neuroendocrine immunity for glioblastoma therapies.

Neuro-oncology·2026

Same author

GABA signaling activation drives glioblastoma progression in female mice through myeloid-derived suppressor cells.

Nature cancer·2026

Same author

DeepFaceMouse enables scalable prediction of large-scale brain activity from facial dynamics in mice.

Cell reports methods·2026

Same author

NeuroPupil: A generalization-first framework for scalable and biologically informative cross-species pupillometry.

bioRxiv : the preprint server for biology·2026

Same author

Corrigendum to "Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid β-peptide and the membrane lipid peroxidation product 4-hydroxynonenal" [Experimental Neurology, vol. 213,1 (2008): 114-21].

Experimental neurology·2026

Same author

Females experience a greater benefit from surgical resection in an immune-dependent manner in a preclinical glioblastoma model.

Neuro-oncology advances·2026

Search research articles

Related Experiment Video

Updated: Jun 27, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Notch: from neural development to neurological disorders.

Justin D Lathia¹, Mark P Mattson, Aiwu Cheng

¹Laboratory of Neurosciences, National Institute on Aging Intramural Research Program, Baltimore, MD 21224, USA.

Journal of Neurochemistry

|December 20, 2008

Summary

Notch signaling, crucial for central nervous system (CNS) development and plasticity, is implicated in neurological disorders. Targeting Notch pathways shows therapeutic potential for CNS diseases.

More Related Videos

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors

Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors

Published on: January 20, 2023

Related Experiment Videos

Last Updated: Jun 27, 2026

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis

Published on: December 12, 2019

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors

Antibody Uptake Assay for Tracking Notch/Delta Endocytosis During the Asymmetric Division of Zebrafish Radial Glia Progenitors

Published on: January 20, 2023

Area of Science:

Neuroscience
Cell Biology
Developmental Biology

Background:

Notch is an integral membrane protein acting as a receptor for cell-surface ligands like Jagged and Delta.
Ligand binding triggers Notch cleavage by gamma-secretase, releasing an intracellular domain that regulates gene expression.
Notch signaling is vital for neural stem cell (NSC) proliferation, survival, self-renewal, and differentiation during CNS development.

Purpose of the Study:

To explore the multifaceted roles of Notch signaling in the central nervous system (CNS).
To investigate the involvement of Notch signaling in both normal CNS function and pathological conditions.
To assess the therapeutic potential of targeting Notch signaling for CNS disorders.

Main Methods:

Review of existing literature on Notch signaling in the CNS.
Analysis of Notch's role in neural stem cell biology and neuronal plasticity.
Examination of Notch pathway involvement in neurological diseases and potential therapeutic strategies.

Main Results:

Notch signaling regulates key aspects of neural stem cell behavior and neuronal plasticity, including learning and memory.
The Notch pathway is implicated in the pathophysiology of CNS disorders such as stroke, Alzheimer's disease, and brain tumors.
Studies in animal models indicate that modulating Notch signaling may offer therapeutic benefits for various CNS conditions.

Conclusions:

Notch signaling is a critical regulator of CNS development, function, and plasticity.
Dysregulation of Notch signaling contributes to the pathology of several neurological diseases.
Targeting the Notch pathway represents a promising therapeutic avenue for treating CNS disorders.