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Polymorphism +17 C/G in matrix metalloprotease MMP8 decreases lung cancer risk

Patricia González-Arriaga1, M Felicitas López-Cima, Ana Fernández-Somoano

  • 1Departamento de Medicina, Unidad de Epidemiología Molecular del Instituto Universitario de Oncología, Universidad de Oviedo, Oviedo, Spain. laboepic.uo@uniovi.es

BMC Cancer
|December 20, 2008
PubMed
Abstract

Insights

Genetic variations in matrix metalloproteinase genes (MMPs) may influence cancer risk. A study found a specific MMP8 gene polymorphism is associated with a reduced risk of developing lung cancer, suggesting its potential as a prognostic marker.

Area of Science:

  • Genetics and Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • Matrix metalloproteinases (MMPs) degrade extracellular matrix, aiding tumor cell invasion.
  • Genetic variations (polymorphisms) in MMP genes can alter MMP expression, influencing cancer development.
  • Investigated associations between MMP1, MMP8, and MMP13 gene polymorphisms and lung cancer risk/progression.

Purpose of the Study:

  • To examine the relationship between specific polymorphisms in MMP1, MMP8, and MMP13 genes and the risk of developing or progressing lung cancer.
  • To determine if these MMP gene polymorphisms impact overall survival in lung cancer patients.

Main Methods:

  • Hospital-based case-control study with 501 lung cancer patients and 510 controls.
  • Genotyping performed using Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP).
  • Statistical analysis included logistic regression, Cox's proportional hazard regression, and Kaplan-Meier survival analysis.

Main Results:

  • MMP1 and MMP13 polymorphisms showed no association with lung cancer risk.
  • A specific MMP8 C/G polymorphism was linked to a statistically significant decrease in lung cancer risk (ORadj = 0.65).
  • Polymorphisms in MMP1, MMP8, and MMP13 did not appear to affect overall survival and were not independent prognostic factors.

Conclusions:

  • The investigated MMP8 gene polymorphism is associated with a reduced risk of developing lung cancer.
  • This MMP8 polymorphism may serve as a potential prognostic marker for lung cancer.

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