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Updated: Jun 27, 2026

Isolation and Characterization of Tumor-initiating Cells from Sarcoma Patient-derived Xenografts
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[Interdigitating dendritic cell sarcoma/tumor: a study of 3 cases].

Mei-Fu Gan1, Hong-Sheng Lu, Jian-Wei Zhang

  • 1Department of Pathology, Taizhou Hospital of Zhejiang Province, Linhai 317000, China. gmeifu@sohu.com

Zhonghua Bing Li Xue Za Zhi = Chinese Journal of Pathology
|December 20, 2008
PubMed
Summary

Interdigitating dendritic cell sarcoma (IDCS) is a rare malignancy. S-100 protein expression is key for diagnosing IDCS, distinguishing it from other tumors.

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Area of Science:

  • Oncology
  • Pathology
  • Immunohistochemistry

Background:

  • Interdigitating dendritic cell sarcoma (IDCS) is a rare malignant neoplasm of dendritic cells.
  • Understanding its pathological features is crucial for accurate diagnosis and patient management.

Observation:

  • This study examined three cases of IDCS, noting gross findings and histological characteristics.
  • Tumor cells were oval to spindle-shaped with pale cytoplasm, grooved nuclei, and were S-100 protein positive.
  • Tumors occurred in the lung, spleen, and lymph nodes, often with lymph node metastasis.

Findings:

  • IDCS exhibits distinct morphologic features, including nests, fascicles, and whorls of tumor cells admixed with lymphocytes and plasma cells.
  • Immunohistochemical analysis confirmed S-100 protein expression in the tumor cells.

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  • Differential diagnosis includes other dendritic cell tumors, lymphomas, and carcinomas.

    • Implications:

    • Accurate diagnosis of IDCS relies on recognizing its unique pathological and immunophenotypic profile.
    • S-100 protein positivity is a critical marker for confirming IDCS.
    • Distinguishing IDCS from similar entities is essential for appropriate treatment strategies.