Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
Combined Effects of Drugs: Synergism01:27

Combined Effects of Drugs: Synergism

Synergism is a useful mechanism where combining two or more drugs is more effective than each constituent used alone. Such combinations are also called supra-additive interactions. The drugs collectively enhance the final therapeutic effect by acting on different targets. Another advantage is that the low dose of each constituent drug is sufficient to achieve the desired effect. This helps reduce the duration of therapy and lower the adverse effects of these drugs.
Such synergistic combinations...
Inhibitors of Bacterial DNA Synthesis01:28

Inhibitors of Bacterial DNA Synthesis

Bacterial pathogens depend on precise and efficient DNA replication to sustain infection. Two type II topoisomerases—DNA gyrase and topoisomerase IV—are critical to this process, as they resolve DNA supercoiling and unlink chromosomes during replication. Fluoroquinolones, synthetic derivatives of quinolones, exploit this mechanism by stabilizing the transient DNA–enzyme cleavage complex, preventing strand religation, and causing lethal double-strand breaks. These antibiotics are selectively...
Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Antimicrobial Effectiveness01:28

Antimicrobial Effectiveness

The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy01:16

Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy

Helicobacter pylori, a resilient gram-negative bacterium, can thrive in the stomach's harsh, acidic environment. Infection with H. pylori leads to a cascade of events within the stomach lining. One of the critical disruptions caused by this bacterium is the interference with somatostatin production, a hormone responsible for regulating acid secretion. This interference tips the balance, escalating acid secretion and diminishing bicarbonate levels. This imbalance compromises the defensive...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Trends, center level practice, and outcomes of heart transplantation in people with HIV.

JHLT open·2026
Same author

Hepatitis B, C, and E viruses in solid organ transplantation: donor and recipient perspectives.

JHLT open·2026
Same author

Melatonin treatment for neonatal encephalopathy.

The Cochrane database of systematic reviews·2026
Same author

Allograft Rejection and the Latent HIV Reservoir in Kidney Transplant Recipients with HIV.

The Journal of infectious diseases·2026
Same author

Human antibody repertoire among kidney donors with and without HIV.

JCI insight·2026
Same author

Phage resistance bidirectionally altered antibiotic susceptibility in Klebsiella pneumoniae via galE mutation.

International journal of antimicrobial agents·2026

Related Experiment Video

Updated: Jun 27, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Antimicrobial therapy for bone and joint infections.

Saima Aslam1, Rabih O Darouiche

  • 1Section of Infectious Diseases, Room 4B-370, Michael E. DeBakey VA Medical Center, 2002 Holcombe Boulevard, Houston, TX 77030, USA. saslam@bcm.edu

Current Infectious Disease Reports
|December 20, 2008
PubMed
Summary

Bone and joint infections pose treatment challenges. This review covers antimicrobial strategies and therapy durations for osteomyelitis, orthopedic infections linked to prostheses, and septic arthritis, addressing a data gap.

Related Experiment Videos

Last Updated: Jun 27, 2026

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials
06:18

A Novel Method to Determine the Longitudinal Antibacterial Activity of Drug-Eluting Materials

Published on: March 3, 2023

Area of Science:

  • Orthopedics
  • Infectious Diseases
  • Pharmacology

Background:

  • Bone and joint infections represent a significant clinical challenge across various medical and surgical disciplines.
  • There is a notable deficiency in comprehensive data regarding the epidemiology, economic burden (work loss), and rehabilitation costs associated with bone infections.
  • Current management often lacks robust evidence-based guidelines.

Purpose of the Study:

  • To review and synthesize current antimicrobial options for bone and joint infections.
  • To provide guidance on the optimal duration of therapy for specific orthopedic infections.
  • To address the lack of data by consolidating information on osteomyelitis, prosthetic joint infections, and septic arthritis.

Main Methods:

  • Literature review of antimicrobial therapies.
  • Analysis of treatment guidelines and clinical studies.
  • Synthesis of data on osteomyelitis, periprosthetic joint infections, and septic arthritis.

Main Results:

  • Outlines available antimicrobial agents for treating bone infections.
  • Discusses recommended treatment durations based on infection type.
  • Highlights key considerations for managing osteomyelitis, prosthetic joint infections, and septic arthritis.

Conclusions:

  • Effective antimicrobial selection and appropriate therapy duration are crucial for managing bone and joint infections.
  • Further research is needed to strengthen the evidence base for epidemiological and economic aspects.
  • This review provides a foundational resource for clinicians managing these complex infections.