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Updated: Jun 27, 2026
Kinase Inhibitor Screening In Self-assembled Human Protein Microarrays
Published on: October 23, 2019
Identifying novel autoantibody signatures in ovarian cancer using high-density protein microarrays
C Geeth Gunawardana1, Nader Memari, Eleftherios P Diamandis
1Department of Pathology and Laboratory Medicine, Mount Sinai Hospital, 6th Floor, Room m6-201, 60 Murray Street, Toronto, ON, Canada.
Objectives:
To identify autoantibody signatures in ovarian cancer using protein microarray technology.
Design And Methods:
Protein microarrays were screened using non-malignant peritoneal fluid (n=30) and ascites fluid pooled from ovarian cancer patients (n=30).
Results:
Fifteen potential tumour-associated antigens were discovered. AASDHPPT showed the strongest signal-to-noise ratio.
Conclusions:
Protein microarrays are suitable for autoantibody discovery in ovarian cancer but the signatures are of low frequency.
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