Related Experiment Videos
The effects of intravenous clonidine on ventilation
R Ooi1, J Pattison, S A Feldman
1Magill Department of Anaesthetics, Westminster Hospital, London.
Anaesthesia
|August 1, 1991
Abstract:
The effects of clonidine, an alpha 2 adrenergic agonist, on ventilation were studied in a group of adult volunteers. The ventilatory variables measured were minute ventilation, respiratory rate, end-tidal carbon dioxide tension and the response to carbon dioxide challenge. We found no differences in minute ventilation, respiratory rate and end-tidal carbon dioxide tension, before and after clonidine administration. However, the ventilatory response to carbon dioxide was significantly attenuated following clonidine, suggesting that clonidine has respiratory depressant effects.