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Updated: Jun 27, 2026
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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
Published on: September 30, 2021
Human hepatocellular carcinoma: expression profiles-based molecular interpretations and clinical applications
1Bek Chai Heah Laboratory of Cancer Genomics, Division of Cellular and Molecular Research, Humphrey Oei Institute of Cancer Research National Cancer Centre, 11 Hospital Drive, Singapore 169610, Singapore. cmrhkm@nccs.com.sg
Cancer Letters
|December 20, 2008
Summary
Hepatocellular carcinoma (HCC), a common liver cancer, presents treatment challenges due to its complexity and late diagnosis. Molecular studies aim to identify biomarkers for improved diagnosis and novel therapies for this challenging disease.
Area of Science:
- Hepatology
- Oncology
- Molecular Biology
Background:
- Primary liver cancer is the fifth most common worldwide, with hepatocellular carcinoma (HCC) comprising over 85% of cases.
- Advanced and metastatic HCC management is difficult due to underlying chronic liver disease, cirrhosis, and the cancer's heterogeneous nature.
- HCC is often diagnosed late due to slow early growth and few symptoms, limiting curative treatment options.
Purpose of the Study:
- To review molecular insights into primary liver cancer, focusing on hepatocellular carcinoma (HCC).
- To translate findings from molecular studies into potential diagnostic and therapeutic strategies.
- To identify biomarkers associated with HCC pathogenesis and progression.
Main Methods:
- Comprehensive molecular studies of primary liver cancer tissues.
- Review of recent findings presented at an HCC workshop.
- Analysis of pathological and functional changes in HCC.
Main Results:
- Molecular studies have generated significant knowledge on liver cancer.
- Identification of potential biomarkers for HCC is a key focus.
- Understanding molecular underpinnings is crucial for developing new treatments.
Conclusions:
- Molecular insights are vital for advancing the diagnosis and treatment of HCC.
- Biomarker discovery holds promise for altering clinical outcomes.
- Further research into the molecular basis of HCC is essential.
