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Familial intracranial aneurysms

Jin Soo Lee1, In Sung Park, Kyung Bum Park

  • 1Department of Neurosurgery, Gyeongsang National University, School of Medicine, Jinju, Korea.

Journal of Korean Neurosurgical Society
|December 20, 2008
PubMed

Insights

Familial intracranial aneurysms rupture at younger ages and are often found in the middle cerebral artery. Screening for subarachnoid hemorrhage (SAH) is recommended for relatives in their fifth or sixth decade.

Area of Science:

  • Neurology
  • Genetics
  • Vascular Surgery

Background:

  • Familial intracranial aneurysms (IAs) present distinct characteristics compared to non-familial cases.
  • Understanding the genetic and clinical patterns of familial subarachnoid hemorrhage (SAH) is crucial for effective management.

Purpose of the Study:

  • To investigate the clinical features of patients with familial SAH.
  • To compare the characteristics of familial IAs with non-familial IAs.

Main Methods:

  • Retrospective analysis of patients treated for SAH between 1993 and 2006.
  • Identification of patients with at least one first-degree relative with SAH.
  • Data collection on family history, aneurysm location, and age at rupture.

Main Results:

  • Twelve patients from six families with familial SAH were identified.
  • Mean age at rupture was 49.75 years, with similar ages among affected relatives.
  • Middle cerebral artery aneurysms were common (42%), while anterior communicating artery aneurysms were rare.

Conclusions:

  • Familial aneurysms rupture earlier and at smaller sizes than non-familial ones.
  • High incidence in the middle cerebral artery and underrepresentation in the anterior communicating artery noted.
  • Screening for SAH is advised for individuals with a sibling history of SAH, particularly in the fifth or sixth decade of life.
Abstract

Keywords:
AneurysmFamilialScreeningSubarachnoid hemorrhage

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