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Updated: Jun 27, 2026

Structure-Guided Design and Development of Novel Cyclophilin A Inhibitors and Ganoderiol-F Derivatives: An In-Silico Approach
Published on: June 23, 2026
Design, synthesis and assaying of potential aquaporin inhibitors
Rose Haddoub1, Michael Rützler, Aélig Robin
1Manchester Interdisciplinary Biocentre (MIB) & The School of Chemistry, University of Manchester, 131 Princess Street, Manchester, M1 7DN, UK.
Abstract:
The aquaporin protein family performs fundamental tasks in the physiology of several organs in the human body. Their roles in several disorders known to involve water movement make them attractive targets for the development of novel drug therapies.This chapter describes assays commonly used to study the water permeability across AQPs. It also describes the effect of some known inhibitors of aquaporins on water permeability, such as mercury, gold, silver, copper, phloretin, tetraethyl ammonium salts and acetazolamide compounds.
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