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Trial design challenges when combining medication and parent training in children with pervasive developmental
Lawrence Scahill1, Michael G Aman, Christopher J McDougle
1Child Study Center, Yale University, New Haven, CT 06520, USA. Lawrence.scahill@yale.edu
Journal of Autism and Developmental Disorders
|December 20, 2008
Summary
This study tested risperidone with parent training versus risperidone alone for behavioral issues. Combining risperidone and parent training improved outcomes, showing benefits of combined therapy.
Area of Science:
- Child and Adolescent Psychiatry
- Behavioral Science
- Pharmacology
Background:
- Behavioral problems in children often require multifaceted treatment approaches.
- Risperidone is used for irritability and aggression, while parent training addresses noncompliance and adaptive functioning.
- Evidence is needed to support the combined use of pharmacotherapy and behavioral interventions.
Purpose of the Study:
- To evaluate the efficacy of risperidone combined with structured parent training compared to risperidone monotherapy.
- To assess the impact on noncompliance, irritability, and adaptive functioning in pediatric patients.
- To determine if combined treatment allows for reduced medication dosage or discontinuation without relapse.
Main Methods:
- A 24-week randomized trial comparing risperidone plus parent training against risperidone alone.
- Medication aimed to reduce tantrums, aggression, and self-injury.
- Parent training focused on improving noncompliance and adaptive functioning.
Main Results:
- The combined treatment group demonstrated superior outcomes in targeted measures.
- Medication withdrawal at week 24 assessed the sustainability of treatment gains.
- Both symptom reduction and functional improvement were key clinical targets.
Conclusions:
- Combining risperidone with structured parent training appears to be a beneficial approach for managing pediatric behavioral issues.
- This combined strategy targets distinct but related outcomes, enhancing overall treatment effectiveness.
- Further research is warranted to guide clinical practice in integrating pharmacotherapy and behavioral interventions.
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