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Related Experiment Video

Updated: Jun 27, 2026

Studying Orthodontic Tooth Movement in Mice

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Published on: August 2, 2024

Odontoblast: a mechano-sensory cell.

Henry Magloire¹, Marie-Lise Couble, Beatrice Thivichon-Prince

¹Laboratoire Odontoblast et régénération dentinaire, Université de Lyon, Villeurbanne Cedex, France. magloire@sante.univ-lyon1.fr

Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution

|December 20, 2008

Summary

Odontoblasts, the cells forming dentine, may act as sensory cells. They sense stimuli via dentinal tubules, potentially playing a key role in tooth pain transmission.

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Area of Science:

Dentistry
Cell Biology
Neuroscience

Background:

Odontoblasts form dentine and are implicated in tooth pain.
These cells possess extensions within dentinal tubules, surrounded by nerve fibers.
The odontoblast-nerve complex may function as a mechano-sensory system.

Purpose of the Study:

To investigate the role of odontoblasts as sensor cells in dentine.
To elucidate the function of primary cilia in odontoblast behavior.
To explore mediators of mechano-transduction in odontoblasts.

Main Methods:

Review of existing literature on odontoblast function and mechano-transduction.
Analysis of evidence for excitable properties in odontoblasts.
Identification of key ion channels and cellular structures involved in sensing.

Main Results:

Odontoblasts possess extensions bathed in dentinal fluid, interacting with nerve fibers.
Mechano-sensitive ion channels (K(Ca), TREK-1) and primary cilia are identified in odontoblasts.
Evidence suggests odontoblasts exhibit excitable properties and may function as sensor cells.

Conclusions:

Odontoblasts are likely involved in signal transduction and mechano-sensation.
The odontoblast-nerve complex represents a unique system for sensing stimuli in dentine.
Further research is needed to fully understand the role of primary cilia in odontoblast sensing.