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Updated: Jun 27, 2026
06:34
A Component-resolved Diagnostic Approach for a Study on Grass Pollen Allergens in Chinese Southerners with Allergic Rhinitis and/or Asthma
Published on: June 4, 2017
Allergies to fruits and vegetables.
Montserrat Fernández-Rivas1, Cristina Benito, Eloína González-Mancebo
1Servicio de Alergia, Hospital Clinico San Carlos, Madrid, Spain. mfernandezri.hcsc@salud.madrid.org
Summary
Fruit allergies in children can stem from pollen or latex sensitization. Two distinct cases highlight how allergen type, like profilins or lipid transfer proteins (LTPs), influences allergic reactions and diagnosis.
Area of Science:
- Allergology
- Immunology
- Clinical Medicine
Background:
- Fruit allergies are common in children and adolescents, arising from primary food sensitization or cross-reactivity with inhalant allergens.
- Allergen stability significantly impacts sensitization pathways and clinical manifestations in fruit allergies.
Observation:
- Case 1: A 14-year-old girl with pollen allergy experienced oral allergy syndrome (OAS) to various fruits, sensitized to profilin.
- Case 2: An 8-year-old girl with no pollen allergy had systemic reactions to fruits, sensitized to lipid transfer proteins (LTPs).
Findings:
- Profilins, labile allergens, cause respiratory sensitization and local reactions (OAS) via cross-reactive IgE antibodies.
- Lipid transfer proteins (LTPs), stable allergens, induce primary sensitization and systemic reactions, resisting digestion and heat.
Implications:
- These cases illustrate two distinct fruit allergy patterns driven by panallergen type (profilins vs. LTPs) and their properties.
- Component Resolved Diagnosis (CRD) offers improved diagnostic value for fruit allergies, aiding routine management.
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